rnz [2019-08-30 17:42:06]

RNase Z

locus: BSU_23840

pI: 5.80

mw: 33.87 kDa

protein length: 307 aa

gene length: 924 bp

function: processing of CCA-less tRNA precursors

product: endoribonuclease Z

essential: yes

ec: 3.1.26.11

synonyms: yqjK

Genomic Context

categories

• [category|SW 3|Information processing] → [category|SW 3.2|RNA synthesis and degradation] → [category|SW 3.2.4|RNases] → [category|SW 3.2.4.2|Endoribonucleases]
• [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.8|tRNA modification and maturation]
• [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

Gene

Coordinates: 2,478,006 → 2,478,929

Phenotypes of a mutant

• essential [Pubmed|12682299]

The protein

Catalyzed reaction/ biological activity

• Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule (according to UniProt)
• 3' end maturation of tmRNA [Pubmed|25402410]

Protein family

• [SW|RNase] Z family (single member, according to UniProt)

Structure

• [PDB|2FK6] (in complex with tRNA-Thr) [Pubmed|22940585], [PDB|1Y44]

Expression and Regulation

Operons

• genes: [gene|C40C5D35ED53D343C8200248FCCB010BAB388054|rnz]-[gene|5189DF2F6144CD2429B5C01B1AD03BAE98307579|rpmGC]
  description: [Pubmed|22383849]

labs

• [SW|Ciaran Condon], IBPC, Paris, France [http://www.ibpc.fr/UPR9073/condon/index_en.html Homepage]

References

Reviews

• 19215776,17599240,25878039

Original Publications

• 17005971,12941704,15654328,16518398,22940585,25402410,24022488,31003868